The location of the clog is unlikely to be reached by the drano. It contains microorganisms that break down organic matter in pipes that can slow water flow. How To Use A Toilet Auger To Unclog A Toilet Toilet Clogged Toilet Unclog Besides that, drano could give you skin burns and it could damage the waste pipes and the toilet. Does drano work to unclog toilets . Since drano has sodium hydroxide it can easily erode plastic and metal pipes over. One of the reasons drano is not ok to use in toilets is that the drains are constructed in a way that the drano, or liquid plumber too, can’t easily get to the clog. Its active ingredients (caustic and bleach) work by breaking down the clog, emitting heat in the process. It’s happened to all of us. The fact that it sits for a while can cause three different problems and all of them are bad. Drano uses caustic or oxidizing chemicals (like lye) to dissolve whatever is clogging a drain. So drano is now sitting in your toilet, ...